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Well studied
antimicrobial

Hexylresorcinol

Characteristics

INCI
Hexylresorcinol
CAS
136-77-6
EC
205-257-4
IUPAC
4-Hexyl-1,3-Benzenediol
Functions
antimicrobial

Description

molecule that is naturally present in the bran of rye and other cereals. It has been used for a long time in the food industry as an "anti-browning agent" for fresh-cut fruits or shrimps. 

It turns out that Hexylresorcinol works as an "anti-browning agent" also in cosmetic products. It is a pretty well-researched molecule with significant tyrosinase (the famous enzyme needed to produce melanin) inhibiting abilities. The clinical study of the manufacturer showed that 0.5% Hexylresorcinol has a comparable skin-lightening effect to gold-standard, 2% Hydroquinone.

Even better, a 12-weeks, double-blind, placebo-controlled study with 65 volunteers confirmed the effectiveness of our skin-lightening molecule and it measured an average of 88% skin-lightening improvement. The study also included before and after photos (always a good sign!) and the skin-lightening was indeed visible and significant (though the pigmentation spots did not completely disappear, just so you have realistic expectations).

Our molecule is also a good team player and seems to work in synergy with skincare-do-it-all Niacinamide. A 2022 study compared 3% Niacinamide on its own and a combination of 0.4% Hexylresorcinol + 3% Niacinamide and found that the combo delivered superior skin tone and anti-ageing benefits significantly better than Niacinamide alone.

Evidence & research

Scientific publications & sources 2
  • 1
    Won, Yen-Kim, et al. "Clinical efficacy and safety of 4-hexyl-1, 3-phenylenediol for improving skin hyperpigmentation." Archives of dermatological research 306.5 (2014): 455-465.
    Find in PubMed
  • 2
    Shariff, Rezwan, et al. "Superior even skin tone and anti‐ageing benefit of a combination of 4‐hexylresorcinol and niacinamide." International Journal of Cosmetic Science 44.1 (2022): 103-117.
    Find in PubMed

Found in products (369 total)

Face Care
Synonyms
(Synovea) Hexylresorcinol 4 Hexylresorcinol 4-Hexylresorcinol Hexylresorcinol⁠ Hexylresorcinol (.1%) Hexylresorcinol (0.5%) Hexylresorcinol (1%) Hexylresorcinol (Synovea Hr) Hexylresorcinol (Synovea) Hexylresorcinol 1.0% Hexylresorcinol(Synovea Hr)