Caratteristica
- INCI
- Madecassoside
- CAS
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34540-22-2
Questo è il numero della sostanza nel registro del Chemical Abstracts Service. Il numero CAS identifica in modo univoco una sostanza indipendentemente dalla lingua, dal nome commerciale o dai sinonimi.
- EC
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252-076-1
Questo è il numero della sostanza nel sistema europeo di identificazione chimica (numero CE), utilizzato nelle banche dati normative europee, tra cui ECHA/CosIng.
- IUPAC
- O-6-Deoxy-Α-L-Mannopyranosyl-(1→4)-O-Β-D-Glucopyranosyl-(1→6)-Β-D-Glucopyranosyl (2Α,3Β,4Α,6Β)-2,3,6,23-Tetrahydroxyurs-12-En-28-Oate
- Funzione
- antioxidant, skin conditioning
Для кого подходит
Descrizione
One of the main biologically active components of the famous medicinal plant, Centella Asiatica, aka Gotu Kola. It has well established wound healing, skin-soothing and antioxidant activities.
There is also a study by La Roche Posay (belongs to L'Oreal) that examined the anti-aging effects of 5% Vitamin C combined with 0.1% Madecassoside. They mention that " Madecassoside is known to induce collagen expression and ⁄ or to modulate inflammatory mediators thus might prevent and correct some signs of aging." The surprisingly long, 6-month study observed "significant improvement of the clinical score for deep and superficial wrinkles, suppleness, firmness, roughness,andskin hydration", but Vitamin C in itself is already an anti-aging superstar, so it is hard to know how much Madecassoside did.
Another promising property of Madecassoside is that it seems to inhibit UV-induced melanin synthesis (test formula with 0.05% MA, used twice a day on 23 volunteers for 8 weeks), making it a great active for hyperpigmentation-prone skin.
If that would not be enough, the French manufacturer (Seppic) also has encouraging in-vivo studies on the molecule. Used at 0.2%, Madecassoside reduces redness and peeling in skin with light atopic dermatitis as well as itching in psoriasis-prone skin.
If you are into Gotu Kola, read more here >>
Evidenza & ricerca
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1
Shen, Xueqing, et al. "Propionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from Centella asiatica." Bioscience, biotechnology, and biochemistry 83.3 (2019): 561-568.Trova in PubMed
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2
Jung, Eunsun, et al. "Madecassoside inhibits melanin synthesis by blocking ultraviolet-induced inflammation." Molecules 18.12 (2013): 15724-15736.Trova in PubMed
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3
Liu, Mei, et al. "Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice." Planta medica 74.08 (2008): 809-815.Trova in PubMed
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4
Haftek, Marek, et al. "Clinical, biometric and structural evaluation of the long‐term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin." Experimental dermatology 17.11 (2008): 946-952.Trova in PubMed
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5
Sasmita, Andrew Octavian, et al. "Madecassoside activates anti‑neuroinflammatory mechanisms by inhibiting lipopolysaccharide‑induced microglial inflammation." International journal of molecular medicine 41.5 (2018): 3033-3040.Trova in PubMed
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