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Avoid
preservative

Methylchloroisothiazolinone

Characteristics

INCI
Methylchloroisothiazolinone
CAS
26172-55-4
EC
247-500-7
IUPAC
5-Chloro-2-Methyl-2H-Isothiazol-3-One
Functions
preservative
EU Restr.
V/39

Who it's for

Face Concern
▼ Sensitive Skin ▼ Rosacea ▼ Eczema
Hair Concern
▼ Dandruff ▼ Flaky scalp ▼ Hair Loss ▼ Frizz ▼ Damage ▼ Split Ends ▼ Bleached Hair ▼ Color-Treated ▼ Hydration ▼ Scalp Health ▼ Sensetive Scalp
Application Area
▲ Face ▲ Body ▲ Hair ▲ Scalp

Description

This totally unpronounceable ingredient (let’s take a shortcut: MCI) is a super effective preservative with both antibacterial and antifungal effects that works at very low concentrations. 

The bad news with it though is that it can sensitize the skin easily (it’s a so-called non-fragrance allergen). It’s not permitted to be used alone, but only with its BFF, methylisothiazolinone (MI), another icky preservative. Together they have a broad spectrum antimicrobial effect but are permitted to be used only in rinse-off products (under 0.0015%).

Frequently Asked Questions about Methylchloroisothiazolinone

What is methylchloroisothiazolinone used for in shampoo and other products?
Methylchloroisothiazolinone is a preservative used to stop the growth of bacteria, yeast, and mold in water-based cosmetics. It is commonly found in rinse-off products like shampoos, conditioners, and body washes, where preservation is important for product safety.
Is methylchloroisothiazolinone safe to use in cosmetics?
It can be safe when used at low, regulated concentrations, but it is also a well-known sensitizer. That means some people can develop allergic contact dermatitis after repeated exposure, so safety depends a lot on the specific product and your skin’s tolerance.
Can methylchloroisothiazolinone cause an allergy or skin reaction?
Yes, it is one of the preservatives most associated with allergic contact dermatitis. Reactions can include redness, itching, burning, rash, or worsening eczema, especially on areas that are exposed often or left on the skin for longer periods.
What is the difference between methylchloroisothiazolinone and methylisothiazolinone?
They are closely related preservatives and are often used together, commonly listed as MCI/MI. Both can trigger sensitization, and people who react to one may also react to the other because of cross-reactivity.
Should I avoid methylchloroisothiazolinone if I have sensitive skin or eczema?
If you have sensitive skin or eczema, it’s often a good idea to be cautious with this ingredient because irritated or compromised skin may react more easily. If you suspect it bothers you, patch testing with a dermatologist and checking ingredient labels can help you identify whether it is a trigger.

Products with Methylchloroisothiazolinone (3 334 total)

Hair
Face Care
Synonyms
+ Methylchloroisothiazolinone 5- Chloro-2- Methyl-4-Isothiazolin-3-One 5- Chloro-2-Methyl -4-Isothiazolin-3-One 5-Chloro-2-Methyl-4-Isothiazolin-3-One Methylchloröisothiazolinone Methylchloroisothiazolinone (26172-55-4) Methylchloroisothiazolinone (Methylchloroisothiazolinone) Methylchloroisothiazolinone (Methylisothiazolinone) Methylchloroisothiazolinone (Metilcloroisotiazolinona) Methylchloroisothiazolinone (Preservative) Methylchloroisothiazolinone+ Methylchloroısothiazolinone