Diaminopyrimidine Oxide

Aminexil — the active ingredient against hair loss

Aminexil is a cosmetic and dermatological asset designed specifically to combat hair loss and maintain the normal life cycle of the hair follicle. Unlike most plant extracts and vitamins, Aminexil is an independent synthetic molecule with a well-defined chemical structure and mechanism of action.

It is important to understand that Aminexil is not a group of INCI components. This is a separate active ingredient, which is usually indicated in the composition as Diaminopyrimidine Oxide. This is the official INCI name for Aminexil.

What is Aminexil from a chemical point of view?

Aminexil is a pyrimidine derivative and is structurally similar to the well-known drug Minoxidil. That is why it is sometimes called the cosmetic analogue of minoxidil. However, these are different substances with different mechanisms of action and different regulatory status.

While Minoxidil belongs to medicines in many countries, Aminexil is used primarily in cosmetic products and cosmeceuticals for the scalp.

How Aminexil works

The main hypothesis of the action of Aminexil is related to the prevention of excessive compaction of the collagen membrane around the hair follicle.

With age, under the influence of hormonal factors, stress, inflammation and microcirculation disorders, a gradual accumulation of tough collagen fibers can occur around the hair root. This process is sometimes called fibrosis or micro-fibrosis of the follicle.

It is believed that excessive tissue compaction impairs the nutrition of the hair follicle, shortens the growth phase of the hair and contributes to its premature loss.

Aminexil helps to maintain the elasticity of the surrounding tissues and maintain the normal functioning of the follicle. As a result, hair can stay in the active growth phase longer and fall out less.

What is Aminexil used for?

The ingredient is most often used in products for:

• temporary hair loss;
• seasonal hair loss;
• stress-related hair loss;
• postpartum hair loss;
• weakened and thinned hair;
• age-related decrease in hair density;
• maintaining hair density in men and women.

Aminexil is not able to create new hair follicles, but it can help preserve existing ones and improve the conditions for their functioning.

What ingredients are usually combined with Aminexil?

Although Aminexil is an independent molecule, it is almost never used alone in cosmetics. Most often, it is included in complexes against hair loss along with other active substances.:

• Arginine;
• Caffeine;
• Niacinamide;
• Biotin;
• Pyridoxine HCl;
• Panthenol;
• Adenosine;
• Madecassoside;
• Resveratrol;
• Stemoxydine;
• Peptide complexes.

For example, in popular ampoules against hair loss from the brands of the L'Oréal group, Aminexil is often combined with arginine, B vitamins and stimulating ingredients to increase the overall effectiveness of the formula.

Benefits for hair and scalp

Regular use of Aminexil products can help reduce the intensity of hair loss, improve the quality of the hair shaft, increase the resistance of hair to mechanical damage and improve the appearance of the hairstyle.

The ingredient shows the greatest effectiveness in the early stages of hair thinning, when the hair follicles are still viable.

Is there any proven effectiveness?

Aminexil has been studied in a number of studies by cosmetics and cosmeceutical manufacturers. The data obtained show the ingredient's ability to reduce hair loss and increase the amount of hair remaining in the growth phase.

However, the volume of independent clinical trials is significantly less than that of Minoxidil. Therefore, in the scientific community, Aminexil is usually considered as a promising cosmetic asset with a moderate evidence base, rather than as a full-fledged replacement for medications for the treatment of androgenetic alopecia.

Possible contraindications

Aminexil is considered a safe cosmetic ingredient and is usually well tolerated by most users.

In rare cases, there may be:

• redness of the scalp;
• slight irritation;
• itching;
• individual sensitivity to the components of the formula.

Most often, such reactions are not associated with Aminexil itself, but with solvents and excipients included in lotions and ampoules.

Conclusion

Aminexil (INCI: Diaminopyrimidine Oxide) is a specialized cosmetic ingredient to combat hair loss. It is not a mixture of several INCI components and is a separate synthetic molecule. The main mechanism of action is associated with maintaining the normal condition of the tissues around the hair follicle and reducing the processes of micro-fibrosis. Due to this, Aminexil is widely used in professional lotions, ampoules and serums to strengthen hair, reduce hair loss and maintain density in men and women.